The relationship between stress and illness has been noticed for a long time. Especially, mental disorder and tissue damage is well known as stress-induced illness state. Therefore, many attempt have been made to inhibit stress-induced health disorder using chemical materials. To achieve this goal, the following experiments were designed to evaluate the effect of SUE on immobilization stress.
And the results were as follows:
1. Immobilization stress enhanced the contents of norepinephrine, epinephrine, and dopamine in frontal cortex of brain, and SUE reduced the synthesis of these neurotransmitters in this tissue.
2. Immobilization stress increased the contents of epinephrine, norepinephrine, dopamine, serotonin in corpus striatum of brain, and these neurotransmitters were decreased by administeration of SUE in rats.
3. Immobilization stress increased the content of epinephrine, norepinephrine, dopamine in hypothalamus of brain, and SUE decreased the contents of these neurotransmitters in this tissue.
4. Norepinephrine, epinephrine, dopamine, serotonin in hippocampus of brain were increased by immobilization stress, and dopamine and serotonin were decreased by administeration of SUE in rats.
5. GOT, GPT in plasma were increased origined from liver damage in immobilization stress, but those were not changed by administeration of SUE.
6. Lipidperoxidation in a various tissue was increased by immobilization stress, and SUE inhibited lipidperoxidation in kidney. But, generally, it was not affected by administeration of SUE.
From these results, it is concluded that SUE posses anti-stress activities, and it is resulted from reduction of epinephrine, norepinephrine, dopamine, serotonin in rat brain frontal cortex, corpus striatum, hippocampus, hypothalamus. But, generally, liver damage, and lipidperoxidation were not inhibited by SUE in immobilization stress.
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